18 days old

Postdoctoral Scholar

Lexington, KY 40507
Job Title Postdoctoral Scholar
Requisition Number DU06649
Department Name 7H180:Molecular and Cellular Biochemistry
Work Location Lexington, KY
Salary Range Based on NIH scale
Type of Position Staff
Position Time Status Full-Time
Required Education


Required Related Experience

Less than 5 years of postdoctoral experience

Required License/Registration/Certification


Physical Requirements

occasional repetitive motion, occasional lifting of objects up to 20 lbs


Monday – Friday 8a-5p, occasional overtime, some weekends required

Job Summary

A position is available on or before September 1, 2020, for a Ph.D. organic chemist with experience in organic synthesis and an interest in medicinal chemistry, pending fulfillment of all requirements pertinent to the COVID-19 crisis. Successful candidates must have experience with various synthetic procedures, NMR techniques, and methods for the characterization of organic compounds. The position carries a competitive salary commensurate with experience. In addition to applying on UK Jobs, candidates should submit an electronic copy of his or her curriculum vita and three letters of recommendation to David Watt (dwatt@uky.edu), Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY 40536-0509. The review of applications will continue until the position is filled. The University of Kentucky is an EEO employer and encourages applications from minorities and women.

Lexington is a city of approximately 300,000 in the Bluegrass region of Kentucky and is well known as a center of the horse racing industry. The University of Kentucky is ranked highly among public universities in the United States.

Representative Publications:

Sviripa, VM; Kril, LM; Zhang, W; Xie, Y; Wyrebek P; Ponomareva, L; Liu, X; Yuan, Y; Zhang, C-G; Watt, DS; Liu, C (2018) Phenylethynyl-substituted Heterocycles Inhibit Cyclin D1 and Induce the Expression of Cyclin-dependent Kinase Inhibitor p21Wif1/Cip1 in Colorectal Cancer Cells MedChemComm, 9(1):87-99. PMCID: PMC5839514.

Fiandalo, MV;. Stocking, JS; Pop, EA; Wilton, JH; Mantione, KM; Li, Y; Attwood, KM; Azabdaftari, G; Wu, Y; Watt, DS; Wilson, EM; Mohler, JL (2018) Inhibition of Dihydrotestosterone Synthesis in Prostate Cancer by Combined Frontdoor and Backdoor Pathway Blockade Oncotarget, 9(13):11227-11242. PMCID: PMC5834294.

Chandrika, NT; Dennis, EK; Shrestha, SK; Ngo, HX; Green, KD; Kwiatkowski, S; Deaciuc, AG; Dwoskin, LP; Watt, DS; Garneau-Tsodikova, S. (2019) N,N’-Diaryl-Bishydrazones in a Biphenyl Platform: Broad Spectrum Antifungal Agents Eur J Med Chem, 164: 273-281. PMCID: PMC6351225.

Turcios, L; Chacon, E; Garcia, C; Eman, P; Jiang, J; Spear, B; Liu, C; Watt, DS; Marti, F; Gedaly, R (2019) Autophagic Flux Modulation by Wnt/β-catenin Pathway in Hepatocellular Carcinoma PLoS One Feb 22;14(2):e0212538. doi: 10.1371/journal.pone.0212538. eCollection 2019. PMCID: PMC6386480.

Johnson, J; Rychahou, P; Sviripa, VM; Weiss, HL; Liu, C; Watt, DS; Evers, BM (2019) Induction of AMPK activation by N,N’-Diarylurea FND-4b decreases growth and increases apoptosis in triple negative and estrogen-receptor positive breast cancers PLoS One, Mar 15;14(3):e0209392. doi: 10.1371/journal.pone.0209392. eCollection 2019. PMCID: PMC6420029.

Xie, Y; Kril, LM; Yu, T; Zhang, W; Frasinyuk, MS; Bondarenko, SP; Kondratyuk, KM; Hausman, E; Martin, ZM; Wyrebek, P; Liu, X; Deaciuc, A; Dwoskin, LP; Chen, J; Zhu, H; Zhan, C-G; Sviripa, VM; Blackburn, J; Watt, DS; Liu, C. (2019) Semisynthetic aurones inhibit tubulin polymerization at the colchicine-binding site and repress PC-3 tumor xenografts in nude mice and myc-induced T-ALL in zebrafish Sci Reports, 9:6439 https://doi.org/10.1038/s41598-019-42917-0. PMCID: PMC6478746.

Zhang, W; Sviripa, V; Kril, L; Yu, T; Xie, Y; Hubbard, W; Sullivan, P; Chen, X; Zhan, C-G; Yang-Hartwich, Y; Evers, BM; Spear, B; Gedaly, R; Watt, DS; Liu, C (2019) An Underlying Mechanism of Dual Wnt Inhibition and AMPK Activation: Mitochondrial Uncouplers Masquerading as Wnt Inhibitors J Med Chem 62:11348-11358.

Howard, KC; Dennis, EK; Watt, DS; Garneau-Tsodikova, S (2020) A Comprehensive Overview of Antifungal Drug Medicinal Chemistry: Perspectives and Promise Chem Soc Rev, in press.

Special Request 1: Three Letters of Recommendation

Skills / Knowledge / Abilities
Does this position have supervisory responsibilities? No
Preferred Education/Experience
Deadline to Apply 07/12/2020
University Community of Inclusion

The University of Kentucky is committed to a diverse and inclusive workforce by ensuring all our students, faculty, and staff work in an environment of openness and acceptance. We strive to foster a community where people of all backgrounds, identities, and perspectives can feel secure and welcome. We also value the well-being of each of our employees and are dedicated to creating a healthy place to work, learn and live. In the interest of maintaining a safe and healthy environment for our students, employees, patients and visitors the University of Kentucky is a Tobacco & Drug Free campus.

As an Equal Opportunity Employer, we strongly encourage veterans, individuals with disabilities, women, and all minorities to consider our employment opportunities.

Any candidate offered a position may be required to pass pre-employment screenings as mandated by University of Kentucky Human Resources. These screenings may include a national background check and/or drug screen.


Posted: 2020-05-13 Expires: 2020-06-12

Career Employment at UK

UK offers fulfilling careers in diverse fields supporting our teaching, research and health care missions. We also offer a compelling benefits package, including a generous retirement savings match and a supportive work environment distinguished by a respect for the unique work-life needs of every individual. Our culture of learning also provides tremendous support and resources for ongoing education, training and development. 

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Postdoctoral Scholar

University of Kentucky
Lexington, KY 40507

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